Land O' Lakes Conference on Drug Metabolism/Applied Pharmacokinetics
September 8-12, 2008
Devil's Head Resort
Merrimac, WI
Developed & Conducted by Extension Services in Pharmacy, School of Pharmacy, University of Wisconsin- Madison.
Registration
Your registration options are as follows:
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Register Online. Login in using your user account. If you don't have a user account creating one is free & easy. |
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Download the registration form, complete & mail to: LOL Drug Metabolism Conference |
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By phone at 608.262.3130 or toll-free at 877-947-4255 using a credit card for payment. |
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Download the registration form, complete & fax to 608.262.2431 using a credit card for payment. |
Conference Goals & Objectives
The purpose of this four-day conference is to provide an educational forum to discuss the current issues in selecting potential new therapeutic entities for preclinical trials and current issues in drug metabolism and preclinical pharmacology. General goals associated with this conference include:
- To provide a better understanding of the role of metabolism in the pharmacokinetics and pharmacodynamics of new product candidates, including biotechnology-derived drugs.
- To evaluate new techniques and shared experiences in the area of “high through-put screening.”
- To gain insight into problems and issues encountered during the drug discovery process and the interface between drug discovery and development.
- To discuss current regulatory issues affecting preclinical and early clinical development, both within the United States and globally.
- To identify processes for improving the identification of successful drug candidates through metabolite identification and in-vitro/in-vivo implications.
- To discuss current drug metabolism systems and their applicability in R&D activity.
- To gain insight from various perspectives on the drug-discovery process, including industry, academia, and regulatory agencies.
Last years course evaluation results.
2008 Conference Planning Committee
- David A. Hartman, Ph.D., Conference Chair, Fulcrum Pharma Developments, Inc., Morrisville, NC
- James L. Ferrero, Ph.D., Metabasis Therapeutics, La Jolla, CA
- Randall H. Guthrie, Xcelience, LLC, Tampa, FL
- Robert J. Guttendorf, Ph.D., Sequoia Pharmaceuticals, Inc., Gaithersburg, MD
- Patrick Koch, Ph.D., Sepracor, Inc. Marlborough, MA
- Gordon Loewen, Ph.D., Valeant Pharmaceuticals, Aliso Viejo, CA
- Mark N. Milton, Ph.D., Tempo Pharmaceuticals Inc., Cambridge, MA
- Ivan Nestorov, Ph.D., ZymoGenetics, Seattle, WA
- Jasminder Sahi, Ph.D., CellzDirect, Ann Arbor MI
- Paul Savina, GlaxoSmithKline, Research Triangle Park, NC
- James M. Schmidt, Lexicon Genetics, The Woodlands, TX
- Arzu Selen, Ph.D., CDER, FDA, Silver Spring, MD
- Michael Sinz, Ph.D., Bristol-Myers Squibb, Wallingford, CT
- Vangala Subrahmanyam, Ph.D., Sai Advantium Pharma Limited, Hinjewadi, India
- Steven Swanson, Ph.D.,Eli Lilly and Company, Indianapolis, IN
- Larry M. Tremaine, Ph.D., Pfizer, Inc., Groton, CT
Conference Support
Speical thanks for unrestricted educational grant to help support this conference from
BD Biosciences |  |
Merch Research Laboratories |  |
NoAb BioDiscoveries Inc. | 
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QPS, LLC |  |
Sai Advantium Pharma, Ltd. |  |
Conference Travel Information
Location & Travel
The conference will be presented at Devil's Head Resort in Merrimac, Wisconsin. Merrimac is approximately 40 minutes from Madison. For those registrants flying into Madison, bus transportation will be available to and from Devil's Head Resort.
Shuttle Bus Service to and from the Dane County Regional Airport
Monday 1:30 and 4:30 PM | Friday 10:45 AM |
Sponsored by: |  |
Conference Fees
Registration Fee |
$1050 |
Lodging & Meals: Single Accommodations |
$575 |
Total Amount |
$1625 |
If Payment received prior to August 18, 2008 |
$250 |
EARLY REGISTRATION |
$1375 |
NOTE: All accommodations at Devil's Head for conference registrants will be processed through Extension Services in Pharmacy. Fees are based on a single accommodation. Additional fees will be assessed for both lodging in the event more than one person occupies a room.
Enrollment Deadlines/Limits
A check in the total amount payable to UNIVERSITY OF WISCONSIN should accompany your application to ensure that space will be held for you. Credit card payment is also acceptable. Total payment will be returned /refunded if space is not available.
In the event your registration is confirmed and at a later date you are unable to personally attend, a refund (less a $50 administrative fee) will be provided August 18; after August 18, no refunds will be made. You may fax your registration (608) 262-2431 with payment to follow no later than August 18. After August 18, space will not be held without receipt of payment.
Social Activities
In addition to the educational benefits of this program, the conference is designed to provide registrants with a relaxing environment to meet and share ideas with colleagues with similar interests and network for future collaborative effort. To this end, Devil's Head Resort offers a variety of activities including tennis, indoor and outdoor swimming pools, mountain bikes, nature trails and one of the finest golf courses in Wisconsin. Golf, at a significantly reduced rate, is available to all registrants during Tuesday and Wednesday afternoons of the conference.
Click here to view photos from 2007
Continuing Education Credit
This program is accredited for 18 hours or 1.8 continuing education
units (CEU's). The University of Wisconsin is approved by the Accreditation
Council on Pharmacy education (formerly the American Council on Pharmacy
Education) as a provider of continuing Pharmacy education.
ACPE # 073-000-08-024-L04-P
For More Information
James E. De Muth, Ph.D., Conference Director
Extension Services in Pharmacy
777 Highland Avenue
Madison, WI 53705
(608) 262-3130
FAX (608) 262-2431
Send Email
2008 Program Outline
Monday, September 8 |
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6:00pm |
Opening Reception
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7:00pm |
Dinner |
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Tuesday, September 9 |
First Plenary Session -Safety Testing and Metabolites |
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8:00am |
Welcome and Conference Overview
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8:15am |
Metabolites: Above and Beyond Current Guidances
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9:15am |
Unique metabolites: Impact on Drug Development
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10:00am |
Break |
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10:30am |
Reactive Metabolites
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11:15am |
How Do You Generate Metabolites?
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12:00pm |
Lunch |
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1:00pm |
Different Strategies in the Development Process(es) for Generating Metabolite Data
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2:45pm |
Boat Tour of Upper Dells
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6:30pm | Dinner | |||
Evening Session
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8:00pm |
Outsourcing: Experiences with Partnering in China
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9:00pm |
Dessert Reception
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Wednesday, September 10 |
Second Plenary Session: New Technologies Applied to Drug Metabolism
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8:00am |
Use of Stem Cells for Drug Selection
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8:55am |
Chimeric Mice
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9:50am |
Break |
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10:10am |
Non-invasive Imaging for PK/PD
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11:05am |
Speeding Up Drug Discovery with DART-based MS
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12:00pm |
Lunch |
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1:00pm |
Round Table Discussions on Problem Solving (90 minutes) Applications of In silico Techniques to Discovery
Bio-analytical Aspects of Drug Metabolism
Utility of Transporter Assays in Drug Discovery vs. Development
Partnering and Outsourcing to China and India: Experiences, Success Stories and Drawbacks
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4:300pm |
Poster Session with Authors |
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4:30pm |
Wine and Cheese Reception
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6:30pm |
Dinner |
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8:00pm |
Round Table Discussions on Problem Solving (90 minutes) Role of DMPK Data on Candidate Progression from Nomination to Regulatory Approval
Outsourcing Research to CROs
Stem Cell Derived Hepatocytes
Potential uses of Accelerator Mass Spec in DMPK
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Thursday, September 11 |
Third Plenary Session: Preclinical and Clinical Models
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8:00am |
System Biology
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8:55am |
Physiologically Based PK/PD Models
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9:50am |
Break |
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10:10am |
Exposure-Response Modeling
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11:05am |
FDA Perspective on Preclinical and Clincal Models
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12:00pm |
Lunch |
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Afternoon Session: In silico and In vitro Data Evaluation
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1:00pm |
In silico Tools and Discovery
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1:45pm |
In vitro Tools and Discovery
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2:45pm |
Tour TBD
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6:30pm |
Dinner |
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Evening Session
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8:00pm |
Personalized Medicine at the Marshfield Clinic
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9:00pm |
Traditional Wisconsin Cheese Boxes
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Friday, September 12 |
Fourth Plenary Session: Biomarker
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8:00am |
Biomarkers: An Overview
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8:50am |
Use of Biomarkers in Safety Testing
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9:40am |
Critical Path Initiatives Related to Biomarkers
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10:20am |
Discussion |
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10:30am |
Adjournment |
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