AREA V. Ketal Tethered Reactions

Ketal tethered intramolecular reactions, specifically intramolecular Diels-Alder [IMDA] and RCM reactions, which are areas that have not been widely studied, are discussed here, as well as an approach to fusidilactone C, a spiroketal-containing natural product that first provoked our interest in ketal tethered strategies. These investigations are significance because they can lead to conceptually and fundamentally different approaches to spiroketal-related complex natural products.



Specifically...