Natural Product Biosynthesis, Engineering, and Drug Discovery

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Biography


C. Richard Hutchinson, Ph.D.


C. Richard Hutchinson, Ph.D., was born in Dayton, OH (1943), attended Ohio State University (B.S. 1966) and the University of Minnesota (Ph.D., 1970). Following postdoctoral work at Cambridge University, England (1971), he was an Assistant Professor (Pharmacognosy, University of Connecticut, 1971-74; Medicinal Chemistry, University of Wisconsin, 1974), Associate Professor and Professor (Medicinal Chemistry and Bacteriology, University of Wisconsin). He retired in March 2000 to join Kosan Biosciences, Hayward, CA as a Vice President and head of New Technologies. In 2004 he returned parttime to the University of Wisconsin, left Kosan in December 2006 and in 2007 founded Centrose LLC together with two other founders. He now is President and Chief Scientific Officer of Centrose LLC and conducts ad hoc teaching and research advising at the University.

During the past 37 years, he has made major advances in understanding the biosynthesis of naturally occurring drugs through studies of the molecular genetics and biochemistry of antibiotic production in microorganisms. Through work on the genetic manipulation of polyketide genes, his laboratory has created novel metabolites, devised methods to purify and study polyketide synthase enzymes, established fermentation routes to pharmaceutically important compounds, and used genetic engineering to develop improved strains of commercially important microorganisms. He is particularly noted for combining biochemical, chemical, and genetic methods in his research. Dr. Hutchinson has published over 240 papers, held numerous federal and industrial research grants and received many prestigious awards, including Guggenheim and Fullbright fellowships, the Charles Thom Research Achievement Award of the Society for Industrial Microbiology, the AACP Paul Dawson Biotechnology Award, the Research Achievement Award of the American Society for Pharmacognosy and a Distinguished Alumni Award from Ohio State University.