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Education:

• B.Sc. 1973 Biochemistry Queen Elizabeth College, London
• Ph.D. 1976 Biochemistry Charing Cross Hospital, London
• Postdoctoral Chester Beatty Research Institute, London

Overview

Timothy received his B.Sc. degree (1973) in biochemistry from Queen Elizabeth College, London University, U.K., and his Ph.D. (1976) in biochemistry from Charing Cross Hospital Medical School, London University. After two years postdoctoral fellowship at the Chester Beatty Research Institute, London, and six years on the staff of the Cancer Research Institute, University of California-San Francisco, he joined the Wisconsin faculty in 1985. His research interests are in drug delivery and gene delivery systems, including the use of antibody-directed liposomes, the selection of carrier dependent drugs, the development of gene delivery vectors based on cationic lipids, and the application of target specific drug delivery to ocular disease, antitumor and antiviral therapy.

My research interests are principally concerned with the application of liposomes as a drug delivery or gene delivery system. I am interested in the transport properties of drugs, the required delivery rate for drugs, and how these properties affect the use of drugs for liposome-mediated intracellular delivery. I am also interested in the mechanism by which drug-carrier complexes and gene-carrier complexes interact with cells, their subsequent processing by endocytosis, digestion, and drug transfer from lysosomes to cytoplasm, and the mechanism by which DNA molecules enter the cell and reach the nuclear compartment.

Work-Related Interests/Research:

Drug delivery and gene delivery systems, including the use of antibody-directed liposomes, the selection of carrier dependent drugs, the development of gene delivery vectors based on cationic lipids, and the application of target specific drug delivery to ocular disease, antitumor and antiviral therapy

Highlighted Publications:

• I. Solodin, C.S. Brown, M.S. Bruno, C.-Y. Chow, E-H. Jang, R.J. Debs and T.D. Heath, "A novel series of amphiphilic imidazolinium compounds for in vitro and in vivo gene delivery," Biochemistry, 34, 13537 (1995).
• J.-S. Kim and T.D. Heath, "Improved in vitro growth inhibitory effect of N-(phosphonacetyl)-L-aspartic acid in immunoliposomes," J. Controlled Rel., 40, 101 (1996).
• C-Y. Chow and T.D. Heath, "Rapid diffusion of the lipid phosphorus of phosphatidylglycerol through polycarbonate membranes is caused by the oxidation of the unsaturated fatty acids," Biochim. Biophys. Acta, 1239, 168 (1995).
• I. Solodin, C.S. Brown and T.D. Heath, "Synthesis of phosphotriester cationic phospholipids. Cationic lipids 2," SYNLETT, No. 5, p. 457 (1996).
• T.D. Heath, C.S. Brown and J.C. Chan, "Anionic liposomes deliver different liposome dependent drugs to cells with variable efficiency: an explanation based on the optimal timing of drug delivery," J. Liposome Res., 9, 81 (1999).