Pre-formulation (drug substance and excipient physical/chemical characterization)
- Solubility
- pH-rate
- Salt form selection
- DSC
- TGA
- XRD
- Dynamic Vapor Sorption
- Microscopy - Optical, Raman
- Solid State Stability
- Stress Testing
- Drug Property Prediction
Formulation
- Small-scale milling - Retsch
- Suspensions/emulsions - Polytron
- Tablets - Carver press, hardness & friability/abrasion testing
- Capsules - manual filling (size 0)
Analytical
- HPLC (Agilent, Dionex)
- Dissolution (Van Kel)
- Gel Electrophoresis
- Osmolality
- Water by KF Titration
Stability
- 40C/75%RH
- 30C/65%RH
- 2C-8C
- -20C
- Photostability